Sangui, ECCPS and TransMIT start biological in vitro experiments aimed at the characterization of hemoglobin polymers

Witten, Germany, April 25, 2014

Staff members of the Excellence Cluster Cardio-Pulmonary System (ECCPS) have started to carry out in vitro experiments aimed at the biological characterization of Sangui's artificial oxygen carrier (hemoglobin hyperpolymers) in laboratories of Giessen University. Target of the tests are the effects of hemoglobin polymers on the blood pressure in freshly isolated ex vivo perfused and ventilated lungs of mice. Native hemoglobin (positive control) and an aqueous colloid/electrolyte solution without hemoglobin (negative control) will serve as comparison perfusion media. All test batches containing hemoglobin are being produced in the Sangui laboratories in Witten, Germany. SanguiBioTech GmbH scientists are accompanying the test series.

Native hemoglobin in the blood plasm generates hypertension, as it effects a constriction of the arteries and arterioles of the blood vessel system. This happens because it permeates the endothelium of the vessels, thereunder it binds (and thus removes) a messenger substance that serves to relax the blood vessels. Sangui assumes that the hemoglobin hyperpolymers developed by the company are too big to permeate the vascular endothelium. Therefore, they will not induce hypertension or only to a negligible degree. This property is an important precondition for the successful application of a blood additive.

In the meantime TransMIT Gesellschaft für Technologietransfer mbH, which is involved in carrying out the project as co-contractor, has informed SanguiBioTech GmbH that due to changes in the formalities required for the appointment of animal protection officers recently imposed by the district president which had to be adopted beforehand by TransMIT, regrettable delays had occurred in the approval process of the animal tests applied for by Sangui. The district president boards in charge of approvals are expected to consult about the application in the course of the month of May 2014.

Sangui BioTech International, Inc. ("SGBI") is a holding company the shares of which are being traded on the OTCQB marketplace (www.otcmarkets.com: SGBI) and the OTC markets of Berlin and Hamburg-Hannover stock exchanges. Its purpose is to provide financing and access to the capital markets for the enterprises of the Sangui group. SanguiBioTech GmbH is a ninety percent subsidiary of Sangui BioTech International, Inc.

For more information please contact:

Joachim Fleing
Phone: +49 (179) 7963472
Fax: +49 (2302) 915191
e-mail: fleing@sangui.de